The hunt for the next 100x crypto has heated up as AVNT crypto token recorded an impressive 48.6% surge amid skyrocketing volume and renewed hype. While Avantis spike is grabbing headlines, analysts are turning their gaze toward BIO Protocol, claiming it might be the true 100x opportunity hiding in the bush.
With crypto Avantis riding the wave of Base-chain derivatives momentum and BIO advancing the DeSci narrative, smart money may be shifting gears. For investors seeking asymmetric upside and FOMO-fuelled plays, this clash of narratives could define altcoin season.
Learn more is the native token of Avantis, a decentralized perpetual exchange built on the Base blockchain, offering zero-fee trading and up to 500x leverage for cryptocurrencies, forex, commodities and real world assets (RWAs). Recent catalysts like reaching $100M TVL, listing on major exchanges, whale accumulation and explosive volume jumps. On-chain data shows over $470M perp volume past 24 hours and smart money wallets increasing holdings.

(Source – defillama)
Technically speaking, we can see that on 1 1-hour time frame, the price has reclaimed the 200 EMA and SMA lines previously acting as resistance. Pushing first to $0.67, then retest the previous resistance now support, retest the support, and push further with volume to $0.76. RSI indicator tapping strongly into the overbought zone and MACD flipping positive, supported by volume, shows the demand is there.

(Source – TradingView)
On 4 4-hour time frame, things don’t sit differently, prices have escaped the resistance and are now eyeing the next one at $0.91. It all comes down to how Bitcoin is going to navigate through this delicate period, expecting many macroeconomic data. If the price manages to reclaim $0.91, then it could go to the next resistance at $1.8, but if it gets rejected out of $0.91, it could go back down to the newly created support.

(Source – TradingView)
For traders seeking the next 100x crypto, AVNT offers high upside, but also high risk, and maybe there is a more suitable pretender.
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Does BIO Protocol Have the Potential to Be the Next 100x Crypto?
BIO Protocol is a decentralized science (DeSci) platform enabling tokenized biotech projects, IP ownership, and community-funded research through BioDAOs.
The price has surged over 65% to $0.136 before settling down to a little under $0.1. That massive pump came with huge volume and the news that the BIO token has been listed on the Upbit exchange.
신규 디지털 자산 바이오프로토콜(BIO) 거래지원 안내
✅ 지원 마켓: KRW, BTC, USDT 마켓
? 거래지원 개시 시점 :2025-10-20 18:00 KST 예정?공지 바로가기: https://t.co/UCizgFo1ZN #Upbit #BIO @BioProtocol pic.twitter.com/lGMtOegIhF
— Upbit Korea (@Official_Upbit) October 20, 2025
That jump in price made the MACD indicator go from high negative to positive. RSI jumped from oversold to above average, suggesting a trend reversal is on the way. Also reclaiming the resistance zone at around $0.1 would be a good ground to create FOMO and push further to the next resistance at $0.16.

(Source – TradingView)
While short-term pullbacks are possible, the long-term thesis holds. Decentralized science is still early, making BIO one of the few projects with true 100x potential.
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Could Bitcoin Hyper Be the Next 100x Crypto Play?
While AVNT and BIO lead the charge in their sectors, Bitcoin Hyper is quietly emerging as one of the best presales of 2025, and possibly the next major exchange listing candidate.
Bitcoin Hyper is one of the first Bitcoin Layer 2 networks, designed to deliver scalability, DeFi functionality, and near-instant BTC transactions using ZK rollups technology. It’s built to transform Bitcoin from a passive store of value into an active, yield-driven ecosystem.
The HYPER presale has already raised over $24.4M, offering tokens at $0.013145 each, with buyers able to stake immediately for up to 49% APY. Also, Bitcoin Hyper technology uses Canonical Bridge, owned by the Solana Virtual Machine (SVM), enabling throughput up to 50,000 TPS, faster than most current L2s.
If HYPER lands a Coinbase or Binance listing, it could mirror the explosive moves seen in early L2 tokens like ARB or OP, which could be the catalyst to be the next 100x crypto play.