Cogent Biosciences (NASDAQ: COGT) experienced a 120% surge in premarket trading on November 10, 2025, after announcing positive results from its Phase 3 trial for bezuclastinib, a treatment for gastrointestinal stromal tumors (GIST). The trial demonstrated that bezuclastinib, when combined with sunitinib, significantly reduced the risk of disease progression or death by 50% compared to sunitinib alone. Following these promising results, Cogent Biosciences plans to submit a New Drug Application in 2026. The drug has also been granted FDA Breakthrough Therapy Designation, highlighting its potential to address unmet medical needs in GIST treatment.
Cogent Biosciences Stock Soars 120% on Positive GIST Drug Trial Results
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